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The anti-inflammatory effect of aloe (Aloe arborescensis) has been known since antiquity. In modern times, you’ll often see aloe being used to treat skin inflammation. This aloe species has also been linked to immunomodulation and has an effect on lymph cells.

Aloe’s anti-inflammatory effect is thought to stem from the activation of complement mechanism in the immune system, and from boosting the mitogenic activity of lymphocytes (Imanishi KI 1993). Other active anti-inflammatory components in aloe include aloenin, barbaloin, aloe-emodin, beta-sitosterol, and a mixture of straight-chain higher alcohols (Yamamoto MM et al 1991).

In Aloe arborescensis, immunomodulative effects are associated with alkaline-soluble polysaccharides that aid lymphocyte transformation (Nazeam JA et al 2017). Researchers have also observed acemannan to have a considerable immunomodulative effecton oluline (Winters WD et al 1981, Davis RH et al 1981).

An interesting compound in aloe leaves is aloctin A. It has several functions, among them an effect on lymph cells (Imanishi K, 1993).